You should read this article and know about Co-enzyme Q10 (CoQ10) benefits, side effects , dosage and foods rich in CoQ10 before trying any supplements.
The number of people taking CoQ10 supplements has steadily increased. This product may influence and affect a variety of conditions, including blood pressure and muscle pain.
In this article I’ll discuss the CoQ10 benefits in relation to muscle pain (caused by statins) and answer the following question:
Is there enough evidence that CoQ10 works and that the benefits justify its cost?
Do you know the answer to the following question?
CoQ10 was first isolated from which one of the followings?
CoQ10 was first isolated from a cow heart by Frederick Crane of Wisconsin, USA, in 1957.
CoQ10 is a potent antioxidant, a cell membrane stabilizer, and an essential co-factor for the lungs.
It helps generate energy. All human cells contain CoQ10, with the highest amounts found in the heart, liver, kidney, and pancreas.
This co-enzyme is measured by high performance liquid chromatography (HPLC).
It’s fat soluble and transported by lipoprotein particles in the circulatory system.
What are the lipoproteins?
These particles are a combination of lipid (fat) and protein and help fats to move through watery environment.
Research studies shown that statins reduce plasma CoQ10.
Statin therapy can reduce plasma CoQ10 concentrations by up to 54%.
The adult reference interval for plasma/serum CoQ10 is approximately 0.5 – 1.7 micromol/L.
How about CoQ10 supplements?
Different brands of CoQ10 supplements are currently available on the market; however, due to lack of standardization, the formulation of these supplements can be significantly different.
The variability of supplements and their bio-availability (the degree that a drug or supplement is absorbed) is based on whether they’re dry powder capsules or dispersed in oil.
Also, the amount of absorbed CoQ10 can vary person to person.
CoQ10 and food
CoQ10 is produced in the body and can also be obtained from food.
Fish (tuna, salmon, sardines, and mackerel), meat, and vegetable oils are good sources of CoQ10 in food.
Food sources of coenzyme Q 10
- Canola oil
Meat products are the largest source of CoQ10 in a person’s diet.
Cholesterol-lowering medications and CoQ10
Cholesterol-lowering medications, specifically statins, are effective and safe drugs that reduce the risk of cardiovascular disease (heart attacks and strokes).
However, statin therapy carries risks of side effects ranging from muscle pain and weakness to a breakdown of muscle fibers.
Muscle pain or weakness, involving a rise in the normal blood creatine kinase levels (CK); typically occur in fewer than one in 10,000 patients on standard doses.
However, this risk varies between medications, and increases with use of higher doses and interacting drugs.
Muscle break down is rarer but carries the risk of kidney failure. The cause behind the muscle pain and discomfort in those taking statins is unclear.
A study in 2007 has suggested that CoQ10 supplementation may relieve the muscle pain associated with starting statin therapy.
However, another study also published in 2007, didn’t find any improvement in muscle pain and discomfort with CoQ10 supplementation, despite the fact that the patients in this study took a higher dosage.
Does CoQ10 lower blood pressure?
Few trials found some evidence that consumption of CoQ10 (100-200 mg per day) could reduce the blood pressure.
Coenzyme Q10 benefits
Some weak evidence suggest that coenzyme Q10 might be useful in treating the following conditions.
- High blood pressure
- Congestive heart failure
- It might reduce the risk of some complications of heart bypass surgery
Most common Coenzyme Q 10 side effects include diarrhea, nausea, suppressed appetite, heart burn, and abdominal discomfort. CoQ10 hasn’t been tested on pregnant or breast feeding women.
Coq10 during pregnancy
The data concerning the safety of CoQ10 during pregnancy is lacking therefore pregnant women should stop taking CoQ10 during pregnancy.
Few studies suggest that cholesterol-lowering medications (especially statins) –can reduce the production of CoQ10 in the cells, resulting in decreased plasma concentration.
But other studies have not confirmed these findings.
After reviewing a wide range of research data, I’ve to say that we don’t have any convincing and reliable data in support of taking CoQ10 for the treatment or prevention of statin related muscle pain.
In my opinion, nevertheless, if taking this supplement can help a patient at risk of having serious heart and vascular complications, to remain on a statin drug, a trial may be worthwhile.
Otherwise, based on current research longer-term treatment with CoQ10 to treat statin-induced muscle pain or weakness can’t be recommended.
Now your turn,
What is your opinion and experience with CoQ10? Go to comments section and tell me more…